Biomechanical factors impact on the development of knee osteoarthritis
Knee osteoarthritis is one of the main causes for pain and disabilities. Aging of the population and the obesity epidemic will increase the number of people affected with knee osteoarthritis. This will lead to an increasing impact on health care and public health systems. The exact reasons for the development of knee osteoarthritis remain unknown. The association between several biomechanical alterations and the development of knee osteoarthritis has been indicated in several biomechanical studies, although a comprehensive systematic review is not available.
The objective of this project is to identify the biomechanical factors that are associated with the development of knee osteoarthritis. From this a tool can be developed, to identify the presence of biomechanical factors that account for an increased risk of developing knee osteoarthritis.
A systematic review about biomechanical factors that are associated with the development of knee osteoarthritis will be performed. Known risk factors for knee osteoarthritis might mediate the association between biomechanical factors and the development of osteoarthritis. Therefore, this will also be reviewed.
The biomechanical factors associated with the development of osteoarthritis might be related to each other in a mechanism. This can be represented by a deterministic model, which will be evaluated by a systematic review.
Another study within this project will aim to provide evidence for one of the missing links within the deterministic model, or strengthen the existing evidence for the link.
In the last study a tool for the early identification of persons at high-risk of developing knee osteoarthritis due to adverse biomechanics will be developed. This tool will be based on the information found in the systematic reviews. In addition, available evidence about the identification of subgroups and biomechanical interventions will be used.
This project will result in an overview of the biomechanical factors that are associated with the development of knee osteoarthritis and the mechanisms behind this. A tool for the identification of persons being at high risk to develop knee osteoarthritis will be based on this knowledge. In addition, the information gathered in this project can be used as framework for future randomized controlled trials that evaluate the effect of biomechanical interventions.