Reus, Elsa

ESR5 Elsa Reus

University of Münster
I joined the KNEEMO ITN in September 2015 as an early stage researcher at the UniversitätsklinikumMünster (Germany). I am a pharmacist from Spain. I studied for my Bachelor in Pharmacy at Miguel Hernández University (Alicante, Spain) and my Master in Clinical Trials at CEU San Pablo University (Madrid, Spain). After this, I worked as a researcher at the pharmacy in Gregorio Marañón Hospital (Madrid, Spain).

Biomechanical effects of different orthotic interventions and their clinical relevance in the daily life of patients with medial compartment knee osteoarthritis.

Knee osteoarthritis is the most common form of arthritis with an estimated lifetime prevalence of 44,7%. While it can occur even in young people, the chance of developing osteoarthritis rises after the age of 45 and is the leading cause of pain and limitations in activities of daily living.
The use of different orthotic devices (footwear, insoles, braces...) as conservative therapy for knee OA is recommended.

The main objective of this project is to compare the immediate biomechanical effect of different orthotic interventions and the clinically relevant outcomes such as knee confidence and patient compliance.
The secondary objective of this study is to assess the midterm effect of an ankle-foot orthosis and it’s compliance within different subgroups of patients.

In addition, a sub-study will focus on the comparison of biomechanical effects of the interventions during stair ascending and descending.

In a cross-over design, patients will be given an intervention (control, ankle-foot orthosis, valgus brace, laterally wedged shoe) in a randomized order and gait analysis will be performed to obtain baseline biomechanical measurements of frontal and sagittal plane kinematics and kinetics. Immediately after wearing each device, patients will be asked to rate their pain and knee confidence. Statistical analysis will determine if there are correlations between biomechanical effects and knee confidence or pain.

Once completed, they will be asked to wear the ankle-foot orthosis for the following six weeks in their daily life. After that, patients will return to the gait lab to repeat the gait analysis once more whilst wearing the orthosis.

The use of orthotic devices has been investigated and implemented as a potential conservative therapy for knee osteoarthritis patients. This study will result in a comparison of the immediate effects of different orthotics on biomechanical parameters, pain and knee confidence.

Furthermore, it will add novel information regarding the effects of a biomechanical intervention on immediate and midterm functional and clinical outcomes in knee osteoarthritis patients.